| | Day | Time | | Opponent | Score | | Record |
| February |
| | 14 | Game 2 | vs. | Lees-McRae | L-9-10 | | 0-1 |
| | | 3:00PM | vs. | Lees-McRae | W-5-4 | | 1-1 |
| % | 17 | 10:00AM | vs. | Pitt CC | L-3-4 | | |
| | Lady Knight Softball Inv. |
| % | | 4:00PM | vs. | Florence Tech | W-6-3 | | |
| | Lady Knight Softball Inv. |
| % | | 6:00PM | vs. | Young Harris College | W-5-2 | | |
| | Lady Knight Softball Inv |
| % | 18 | 10:00AM | vs. | Louisburg College | L-1-5 | | |
| | Lady Knight Softball Inv |
| | 25 | 12:00PM | vs. | Alderson-Broaddus College | L-0-5 | | 1-2 |
| | Tusculum Inv. |
| | | 4:00PM | @ | Tusculum | L-0-10 | | 1-3 |
| | Tusculum Inv. |
| | 26 | 12:00PM | vs. | University of Findlay | W-6-1 | | 2-3 |
| | Tusculum Inv. |
| | | 4:00PM | @ | Tusculum | T-4-4 (5) | | 2-3-1 |
| | Tusculum Inv. |
| March |
| | 1 | 2:00PM | @ | University of the Cumberlands | W-4-3 | | 3-3-1 |
| | | Game 2 | @ | University of the Cumberlands | L-2-5 | | 3-4-1 |
| | 10 | 10:00AM | vs. | Lee University | L-1-11 | | 3-5-1 |
| | NFCA NAIA Leadoff Classic |
| | | 12:00PM | vs. | Olivet Nazarene University | L-0-6 | | 3-6-1 |
| | NFCA NAIA Leadoff Classic |
| | | 9:00PM | vs. | Point Loma Nazarene | L-2-14 | | 3-7-1 |
| | NFCA NAIA Leadoff Classic |
| | 11 | 10:00AM | vs. | Thomas University | L-2-5 | | 3-8-1 |
| | NFCA-NAIA Leadoff Classic |
| | | 2:00PM | vs. | Columbia College | L-2-11 | | 3-9-1 |
| | NFCA NAIA Leadoff Classic |
| | 16 | 1:00PM | @ | Emory & Henry | W-5-2 (9) | | 4-9-1 |
| | Milligan - Megan Aldridge 3 run home run in the top of the 9th |
| | | Game 2 | @ | Emory & Henry | W-7-5 | | 5-9-1 |
| | Maegan Gotchall & Leah Fritts 2-3 at the plate |
| * | 18 | 1:00PM | vs. | King College | W-6-4 | | 6-9-1 1-0 |
| | Milligan - Sarah Smith 3-3 2 RBI, Jennifer Wise & Alicia Dick 2-3 each |
| * | | Game 2 | vs. | King College | L-5-6 | | 6-10-1 1-1 |
| | Milligan - Jennifer Wise 2-3, 2 2Bs & 3 RBIs, Heather Poindexter 2-3 |
| | 23 | 1:00PM | vs. | Maryville College | L-0-1 | | 6-11-1 |
| | | Game 2 | vs. | Maryville College | W-7-4 | | 7-11-1 |
| | Milligan - Sarah Smith 3-4, 2B & 2 SB, Mallory Tincher 2-2 2 runs & solo home run, Alicia Dick CG, 7 IP 2 ER, 3 Ks |
| * | 29 | 1:30PM | vs. | Brevard College | L-1-9 | | 7-12-1 1-2 |
| | Rescheduled from 3-28 |
| * | | Game 2 | vs. | Brevard College | L-0-3 | | 7-13-1 1-3 |
| | Rescheduled from 3-28 |
| April |
| * | 1 | 2:00PM | @ | Virginia Intermont | W-7-6 | | 8-13-1 2-3 |
| | Milligan head coach Wes Holly picks up career win 499 |
| * | | Game 2 | @ | Virginia Intermont | L-0-2 | | 8-14-1 2-4 |
| * | 5 | 2:00PM | @ | Montreat | L-1-4 | | 8-15-1 2-5 |
| * | | Game 2 | @ | Montreat | W-6-2 | | 9-15-1 3-5 |
| | Milligan's Wes Holly picks up his 500th career victory |
| * | 10 | Game 2 | vs. | Union | W-10-1 | | 10-15-1 4-5 |
| | Rescheduled from April 8 |
| * | | 2:00PM | vs. | Union | W-8-0 | | 11-15-1 5-5 |
| | Rescheduled from April 8 |
| * | 11 | 1:00PM | vs. | UVA-Wise | W-5-3 | | 12-15-1 6-5 |
| | Milligan - Laken Stewart, Brooke Dowdy & Jennifer Wise 2 hits each |
| * | | Game 2 | vs. | UVA-Wise | L-0-8 (6) | | 12-16-1 6-6 |
| | UVA-Wise Mallory Mazur CG, 0 R, 2 H, 9 K |
| | 18 | 5:00PM | vs. | Emory & Henry | W-9-4 | | 13-16-1 |
| | 2006 Tennessee - Virginia State Line Classic |
| * | 23 | 2:00PM | @ | Tennessee Wesleyan | L-2-3 | | 13-17-1 6-7 |
| * | | Game 2 | @ | Tennessee Wesleyan | L-3-4 (8) | | 13-18-1 6-8 |
| * | 24 | 1:00PM | @ | Bluefield | W-5-0 | | 14-18-1 7-8 |
| | MILL: Jennifer Wise - 7 IP, 0 runs, 2 hits, 5 K's, 0 BB's |
| * | | Game 2 | @ | Bluefield | W-9-8 | | 15-18-1 8-8 |
| | BLUE: Erin Spaulding - 3-for-4, two RBI's, two runs; MILL: Brooke Dowdy - 4-for-4, two RBI's |
| | 25 | 2:00PM | vs. | University of the Cumberlands | L-0-3 | | 15-19-1 |
| | | Game 2 | vs. | University of the Cumberlands | L-3-13 (6) | | 15-20-1 |
| | 29 | 2:00PM | @ | Maryville College | L-2-3 (8) | | 15-21-1 |
| | | Game 2 | @ | Maryville College | W-7-4 | | 16-21-1 |
| May |
| | 3 | 5:00PM | vs. | Virginia Intermont | W-2-0 | | 17-21-1 |
| | AAC Softball Tournament |
| | | 9:00PM | vs. | Tennessee Wesleyan | L-0-8 | | 17-22-1 |
| | AAC Softball Tournament |
| | 4 | 5:00PM | vs. | King College | L-1-3 | | 17-23-1 |
| | AAC Softball Elimination Game |
